Janeway's Immunobiology

£9.9
FREE Shipping

Janeway's Immunobiology

Janeway's Immunobiology

RRP: £99
Price: £9.9
£9.9 FREE Shipping

In stock

We accept the following payment methods

Description

The effects of bacterial lipopolysaccharide on macrophages are mediated by CD14 binding to Toll-like receptor 4 HIV infection leads to low levels of CD4 T cells, increased susceptibility to opportunistic infection, and eventually to death Downstream events are mediated by proteins that associate with the phosphorylated tyrosines and bind to and activate other proteins T cells also originate in the bone marrow, but all the important events in their development occur in the thymus The T-cell receptor loci comprise sets of gene segments and are rearranged by the same enzymes as the immunoglobulin loci

A specific response against infection by potential pathogens, such as the of antibodies against a particular pathogen, is known as adaptive immunity because it develops during the lifetime of an individual as an adaptation to infection with that pathogen. Rearrangement at the immunoglobulin light-chain locus leads to cell-surface expression of the B-cell receptor Transcription of the HIV provirus depends on host cell transcription factors induced upon the activation of infected T cells Peptides are stably bound to MHC molecules, and also serve to stabilize the MHC molecule on the cell surfaceNewly synthesized MHC class I molecules are retained in the endoplasmic reticulum until they bind peptide

An important question is whether vaccination can be used therapeutically to control existing chronic infectionsIt was soon clear that specific antibodies could be induced against a vast range of substances, called antigens because they could stimulate antibody generation. The Fc receptors of accessory cells are signaling receptors specific for immunoglobulins of different isotypes Proliferating T cells differentiate into armed effector T cells that do not require co-stimulation to act

The effector functions& of T cells are determined by the array of effector molecules they produce. 8-18 Cytokines can act locally or at a distance The crystal structures of several MHC:peptide:T-cell receptor complexes all show the same T-cell receptor orientation over the MHC:peptide complex

Contents

T cells specific for self antigens can cause direct tissue injury and have a role in sustained autoantibody responses

Autoantibodies against extracellular antigens cause inflammatory injury by mechanisms akin to type II and type III hypersensitivity reactions The two classes of MHCmolecule have distinct subunit structures but similar three-dimensional structures. / 3-15 Peptides are stably bound to MHC molecules, and also serve to stabilize the MHC molecule on the cell surface Mucosa-associated lymphoid tissue is located in anatomically defined microcompartments throughout the gut Fully phosphorylated ITAMs bind the protein tyrosine kinases Syk and ZAP-70 and enable them to be activatedMost IgE is cell-bound and engages effector mechanisms of the immune system by different pathways from other antibody isotypes Activation of Toll-like receptors triggers the production of pro-inflammatory cytokines and chemokines, and the expression of co-stimulatory molecules Jenner’s strategy of vaccination was extended in the late 19th century by the discoveries of many great microbiologists. The second phase of the primary B-cell immune response occurs when activated B cells migrate to follicles and proliferate to form germinal centers



  • Fruugo ID: 258392218-563234582
  • EAN: 764486781913
  • Sold by: Fruugo

Delivery & Returns

Fruugo

Address: UK
All products: Visit Fruugo Shop