a b Health Canada (20 July 2005). "Dietary Reference Intakes". Government of Canada. Archived from the original on 14 June 2018 . Retrieved 20 June 2018. Maciejewski-Lenoir D, Richman JG, Hakak Y, Gaidarov I, Behan DP, Connolly DT (December 2006). "Langerhans cells release prostaglandin D2 in response to nicotinic acid". The Journal of Investigative Dermatology. 126 (12): 2637–46. doi: 10.1038/sj.jid.5700586. PMID 17008871.

Nadmiar niektórych substancji może być tak samo groźny, jak ich niedobór. Właśnie tak jest z cenną niacyną. Gille A, Bodor ET, Ahmed K, Offermanns S (2008). "Nicotinic acid: pharmacological effects and mechanisms of action". Annual Review of Pharmacology and Toxicology. 48 (1): 79–106. doi: 10.1146/annurev.pharmtox.48.113006.094746. PMID 17705685. Pitsavas S, Andreou C, Bascialla F, Bozikas VP, Karavatos A (March 2004). "Pellagra encephalopathy following B-complex vitamin treatment without niacin". International Journal of Psychiatry in Medicine. 34 (1): 91–5. doi: 10.2190/29XV-1GG1-U17K-RGJH. PMID 15242145. S2CID 29070525. Archived from the original on 10 July 2012 . Retrieved 27 November 2009. a b c d e f g h i j k Institute of Medicine (1998). "Niacin". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. pp.123–149. ISBN 978-0-309-06554-2. Archived from the original on 1 September 2018 . Retrieved 29 August 2018.Kluczową rolą niacyny w naszym organizmie jest synteza koenzymów dinukleotydu nikotynamidoadeninowego (NAD) i fosforanu dinukleotydu nikotynamidoadeninowego (NADP), które biorą udział w ponad 400 reakcjach biochemicznych w organizmie i to głównie związanych z pozyskiwaniem energii z jedzenia, które spożywamy.

Knip M, Douek IF, Moore WP, Gillmor HA, McLean AE, Bingley PJ, Gale EA (November 2000). "Safety of high-dose nicotinamide: a review". Diabetologia. 43 (11): 1337–45. doi: 10.1007/s001250051536. PMID 11126400. a b c d e f "NIACOR-niacin tablet". DAILYMED, US National Library of Medicine. March 2020. Archived from the original on 9 August 2020 . Retrieved 9 May 2020. Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology, 28(S1), 15–22. https://doi.org/10.1111/exd.13819Wise A, Foord SM, Fraser NJ, Barnes AA, etal. (March 2003). "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry. 278 (11): 9869–74. doi: 10.1074/jbc.M210695200. PMID 12522134. Domanico D, Verboschi F, Altimari S, Zompatori L, Vingolo EM (2015). "Ocular Effects of Niacin: A Review of the Literature". Med Hypothesis Discov Innov Ophthalmol. 4 (2): 64–71. PMC 4458328. PMID 26060832.

a b CRC Handbook of Chemistry and Physics, David R. D.R. Lide (red.), wyd. 88, Boca Raton: CRC Press, 2007, s. 3-450, ISBN 978-0-8493-0488-0 ( ang.). Mani P, Rohatgi A (August 2015). "Niacin Therapy, HDL Cholesterol, and Cardiovascular Disease: Is the HDL Hypothesis Defunct?". Curr Atheroscler Rep. 17 (8): 43. doi: 10.1007/s11883-015-0521-x. PMC 4829575. PMID 26048725. Wan Z, Zheng J, Zhu Z, Sang L, Zhu J, Luo S, Zhao Y, Wang R, Zhang Y, Hao K, Chen L, Du J, Kan J, He H. Wan Z, et al. Front Nutr. 2022 Dec 13;9:1031502. doi: 10.3389/fnut.2022.1031502. eCollection 2022. Front Nutr. 2022. PMID: 36583209 Free PMC article. Review. Szczególnie narażone na niedostateczną podaż niacyny mogą być osoby niedożywione, osoby starsze, nadużywające alkoholu, z zaburzeniami wchłaniania jelitowego, z zaburzeniami wchłaniania tryptofanu, czy osoby nadużywające cukru.

For many years, doses of 1 to 3 grams of nicotinic acid (another name for niacin) per day have been used as a treatment for high blood triglyceride levels.

The production of niacin creates nitrous oxide as a by-product, which is a potent greenhouse gas. In 2018, it was discovered that a niacin factory in Visp, Switzerland, was responsible for around one percent of the country's greenhouse gas emissions. Eventually, catalytic scrubbing technology that avoids most of the emissions was installed in 2021. [86] Chemistry [ edit ] In the United States, prescription niacin, in immediate-release and slow-release forms, is used to treat primary hyperlipidemia and hypertriglyceridemia. [23] [24] It is used either as a monotherapy or in combination with other lipid-modifying drugs. Dosages start at 500mg/day and are often gradually increased to as high as 3000mg/day for immediate release or 2000mg/day for slow release (also referred to as sustained release) to achieve the targeted lipid changes (lower LDL-C and triglycerides, and higher HDL-C). [23] [24] Prescriptions in the US peaked in 2009, at 9.4 million [ citation needed] and had declined to 800 thousand by 2020. [18] Lai E, De Lepeleire I, Crumley TM, Liu F, Wenning LA, etal. (June 2007). "Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1". Clinical Pharmacology and Therapeutics. 81 (6): 849–57. doi: 10.1038/sj.clpt.6100180. PMID 17392721. S2CID 2126240.stumbled across the so-called anti-aging molecule, NAD. You have probably also seen it called NAD+ and maybe even as NADH.