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Gomez TS, Billadeau DD . A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell 2009; 17: 699–711.

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Edwards, D. N. et al. Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer. J Clin. Invest. 131, e140100 (2021). a) Immunoblots of ectopic human (hu) DDR1 and endogenous mouse DDR1 in cell lysates and medium of E0771-derived cells. ( b) Tumour growth curve of E0771-derived Ddr1-WT, KO+EV, KO+huDDR1 cells (n = 7 tumours/group).( c) Transwell migration assay for purified CD8 + T cells in the presence of conditioned medium from E0771 cells containing endogenous WT DDR1, Ddr1-KO, or Ddr1-KO and ectopic expression of huDDR1 (n = 3 technical repeats). Value of migrated CD8 + T cell number with parental E0771-conditioned medium is set at “1”. ( d) Quantification of CD8 + T cell migration in the presence of DDR1-neutralizing antibodies, using conditioned medium from E0771 Ddr1-KO or KO+huDDR1 cells (IgG: n = 4, #3,#9,#14,#33: n = 2, technical repeats). Control: isotype IgG; anti-DDR1 antibody: #3, #9, #14, and #33. Value of migrated CD8 + T cell number in the far-left column is set at “1”. ( e) Tumour curves treated with control IgG, #3, #9, #14, and #33 (n = 8 tumours/group). Antibody administration started when tumour volume reached approximately 100 mm 3. All p values were compared to the control IgG group and p value as indicated. ( f) Tumours host survival curves of E0771 Ddr1-KO tumour cells with ectopically expressed human (hu) DDR1 in C57BL/6 hosts treated intratumorally with isotype IgG (Ctrl, n = 17, tumours) or anti-DDR1 antibody #9 (n = 18, tumours). ( g) Host body weight treated with control IgG, #3, #9, #14, and #33 (Ctrl n = 4 mice, #3, #9, #14, and #33 n = 4 mice/group). Antibody administration started when tumour volume reached approximately 100 mm 3. Data are presented as mean values +/− SEM. ( h, i) E0771 KO+huDDR1 tumours in C57BL/6 (n = 8 tumours/group, h) and Rag1 −/− hosts (n = 6 tumours/group, i) treated with either isotype IgG or anti-DDR1 #33 antibody. ( j, k) Tumour volume (j) and survival curve (k) of M-Wnt KO+huDDR1 tumours in C57BL/6 mice treated with isotype IgG and anti-DDR1 antibody #9 (n = 10, tumours/group). ( l, m) Tumour growth (l) and survival percentage (m) of AT-3 KO+huDDR1 tumours in C57BL/6 mice treated with isotype IgG and anti-DDR1 antibody #3 (n = 10, tumours/group). Values represent mean ± SEM. p value as indicated. Tumour volumes were examined by two-way ANOVA; survival analysis was examined by log-rank (Mantel–Cox) test, and migration assay were examined by two-tailed Student’s t-test. Valiathan, R. R., Marco, M., Leitinger, B., Kleer, C. G. & Fridman, R. Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev. 31, 295–321 (2012). Yamazaki S, Yamamoto K, de Lanerolle P, Harata M . Nuclear F-actin enhances the transcriptional activity of beta-catenin by increasing its nuclear localization and binding to chromatin. Histochem Cell Biol 2016; 145: 389–399.

van den Boom J, Wolter M, Blaschke B, Knobbe CB, Reifenberger G . Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. Int J Cancer. 2006; 119: 2330–2338. Join us on our 14 month BIT Apprenticeship scheme and you will be trained on our process paths while also growing O'Hara A, Simpson J, Morin P, Loveridge CJ, Williams AC, Novo SM et al. p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-kappaB subunit. J Cell Sci 2014; 127: 3659–3665. Clark TG, Rosenbaum JL . An actin filament matrix in hand-isolated nuclei of X. lavis oocytes. Cell 1979; 18: 1101–1108.

Carafoli, F. et al. Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling. Structure 20, 688–697 (2012). Gruosso, T. et al. Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers. J. Clin. Invest. 129, 1785–1800 (2019).

Department of Medicine, The Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA Lim KL, Chew KCM, Tan JMM, Wang C, Chung KKK, Zhang Y et al. Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J Neurosci 2005; 25: 2002–2009. Xiujie Sun, Bogang Wu, Huai-Chin Chiang, Xiaowen Zhang, Madeleine Prevost, Debarati Banik & Rong Li Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M et al. The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Cancer Res 2011; 71: 2938–2948. ProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del Llobregat, Barcelona, SpainOver the course of the apprenticeship you will be introduced to the fundamental operational excellence modules and Under revised ISA 701, auditors must now include the threshold set for overall materiality and performance materiality in the auditor’s report, as well as an explanation of the significant judgements made by the auditor in determining both overall materiality and performance materiality. This might include, for example, the rationale for the determination of performance materiality, as well as the rationale for a change in basis or any significant revisions to both overall and performance materiality through the course of the audit. Given the profound impact COVID-19 has recently had on businesses, this may be particularly relevant in the current environment. When do the revisions take effect? Kaur, A. et al. Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility. Cancer Discov. 9, 64–81 (2019).

Le PU, Angers-Loustau A, de Oliveira RM, Ajlan A, Brassard CL, Dudley A et al. DRR drives brain cancer invasion by regulating cytoskeletal-focal adhesion dynamics. Oncogene 2010; 29: 4636–4647. Apprenticeships are perfect if you want to combine theoretical learning with practical, hands-on experience (and a a–d) Indicated TIL numbers normalized by tumour weight in E0771 KO+huDDR1 tumours from C57BL/6 mice treated with control and anti-DDR1 antibody #9 (n = 4 tumours/group). ( e–h) Percentage of Ki67-positive cells in CD4 +, CD8 + T cells and percentage of IFNγ- or GZMB-positive cells in CD8 + T cells from the same antibody-treated mice as in ( a–d) (n = 4 tumours/group). n.s. not significant. ( i) Representative images of transplanted mammary tumours treated with Ctrl or anti-DDR1 #9 antibody, analysed by SHG, To-pro-3 staining, and collagen fibre individualization. Scale bar: 50 µm. ( j) Quantification of CD8 + T cells in tumour margin and core in control and anti-DDR1 antibody-treated E0771 KO+huDDR1 tumours (Ctrl: n = 8 tumours, #9: n = 9 tumours). ( k, l) TILs from spontaneous mammary tumours (C57B/6) treated with Ctrl or anti-DDR1 #9 antibody under the pre-tumour ( k) and post-tumour ( l) conditions. n = 6 tumours/group. ( m, n) Representative IHC images of CD3 + and CD8 + T cells in tumour margin and core in control and anti-DDR1 antibody-treated E0771 KO+huDDR1 tumours. Tumour boarder denoted by red dash lines. Box areas at higher magnification are shown in the inlets. Red arrow heads indicate CD8 + cells. Scale bar: 100 µm and 10 µm in inlet. ( o) Representative images of tumours from the post-tumour treatment group, analysed by SHG, To-pro-3 staining, and collagen fibre individualization. Scale bar: 50 µm. ( p) Quantification of tumour fibre alignment in pre- and post-tumour treatment in C57BL/6 hosts (n = 5 tumours/group). Values represent mean ± SEM. p value as indicated, two-tailed Student’s t-test. Muller PA, van de Sluis B, Groot AJ, Verbeek D, Vonk WI, Maine GN et al. Nuclear-cytosolic transport of COMMD1 regulates NF-kappaB and HIF-1 activity. Traffic 2009; 10: 514–527. Masana M, Su YA, Liebl C, Wang XD, Jansen L, Westerholz S et al. The stress-inducible actin-interacting protein DRR1 shapes social behavior. Psychoneuroendocrinology 2014; 48: 98–110.Mu P, Nagahara S, Makita N, Tarumi Y, Kadomatsu K, Takei Y . Systemic delivery of siRNA specific to tumor mediated by atelocollagen: combined therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer. Int J Cancer 2009; 125: 2978–2990.