The new edition brings this remarkable text into a new era. Like its predecessors, Lehninger Principles of Biochemistry, Sixth Edition strikes a careful balance of current science and enduring concepts, incorporating a tremendous amount of new findings, but only those that help illustrate biochemistry’s foundational principles. With this edition, students will encounter new information emerging from high throughput DNA sequencing, x-ray crystallography, and the manipulation of genes and gene expression, and other techniques. In addition, students will see how contemporary biochemistry has shifted away from exploring metabolic pathways in isolation to focusing on interactions among pathways. They will also get an updated understanding of the relevance of biochemistry to the study of human disease (especially diabetes) as well as the important role of evolutionary theory in biochemical research. Expanded and updated section on lipid rafts and caveolae includes new material on membrane curvature and the proteins that influence it, and introduces amphitropic proteins and annular lipids This edition provides a new learning path for students, through emphasis on the fundamental principles of biochemistry. Mechanism Figures features step-by-step descriptions to help students understand the reaction process. Animated Techniques are short animations of laboraatory techniques. Designed to provide students with an overview of protocol, these animations give students a conceptual understanding of what is happening at the chemical level.

Lehninger Principles of Biochemistry, 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry.New medical box on how the high rate of glycolysis in cancerous tissue aids cancer diagnosis and treatment More than 600 end-of-chapter problems (all available in Achieve) give students further opportunity to practice what they have learned. An interactive e-book with embedded multimedia and features for highlighting, note-taking and accessibility support

New box on G proteins, proteins that regulate their GTPase activity, and the medical consequences of defective G protein function Clear writing and illustrations…Clear explanations of difficult concepts…Clear communication of the ways in biochemistry is currently understood and practiced. For over 35 years, in edition after bestselling edition, Principles of Biochemistry has put those defining principles into practice, guiding students through a coherent introduction to the essentials of biochemistry without overwhelming them. New section, Chemical logic and common biochemical reactions, discusses common biochemical reaction typesSynthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing! Interactive Metabolic Map and Animated Mechanism Videos, problem-solving videos, and case studies are integrated into Lecture Slides and available as stand-alone resources Insights on top learning objectives and assignments to review are surfaced just-in-time (7 day period)