Delicol, както всяко друго лекарство, може да предизвика нежелани реакции. Все пак трябва да се помни, че те няма да се появят на всеки и че обикновено ползите от употребата на препарата надвишават възможните рискове, свързани със страничните ефекти. Rifampicin induces CYP 3A4 in the liver thus increasing the metabolism of morphine, codeine and methadone. The effect of these opioids is thereby decreased or counteracted. Opioids may inhibit the hypothalamic–pituitary–adrenal (HPA) or gonadal axis at multiple levels and is most pronounced after long term use.

Treatment should be initiated and supervised by a specialist, i.e. oncologist or gastroenterologist. Dropizol is not recommended during pregnancy unless the benefits clearly outweigh the risks to both mother and child. Should only be used with caution in patients in high-risk groups, such as patients with epilepsy and hepatic disease. Morphine may precipitate coma in hepatic impairment – avoid or reduce dose. See Sections 4.3 and 4.4. Repeated administration may cause dependence and tolerance and the use of opium may lead to addiction to the substance. Particular caution should be exercised in individuals predisposed to addiction to narcotics and alcohol.The use of opium is well-established for treatment of diarrhoea in the clinic. Controlled clinical studies is not available. Concomitant use of Dropizol and sedative medicines such as benzodiazepines or related drugs may result in sedation, respiratory depression, coma and death. Delicol. Жените, които са бременни или планират да забременеят, трябва да се консултират предварително с лекаря си. Delicol – взаимодействия

Avoid use in older adults with a history of falls or fractures as ataxia, impaired psychomotor function, syncope, and additional falls may occur. If use is necessary, consider reducing use of other CNS-active agents that increase risk of falls and fractures and implement other strategies to reduce risk of falls. Vì vậy, bổ sung enzyme lactase sẽ đem lại nhiều lợi ích trong việc cải thiện các tình trạng dưới đây: 1.1. Kém hoặc không dung nạp Lactose Administer at reduced doses and with the utmost caution to patients who are also being treated with other narcotic agents, sedatives, and tricyclic antidepressants and MAO-inhibitors (see also section 4.2). Due to the ethanol content, Dropizol should not be used concomitantly with disulfiram or metronidazole. Both of these drugs can cause disulfiram-like reactions (flushing, rapid breathing, tachycardia). Opium alkaloids are extensively metabolized to glucuronide conjugates (3-glucuronide (M3G) and 6-glucuronide (M6G)) that undergo an enterohepatic cycle. 6-glucuronide is a metabolite of morphine about 50 times more active than the parent substance.

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Particular caution should be exercised when prescribing this drug due to its morphine content. The treatment period should be as short as possible. The posology should be individualized to use the lowest effective dose for the shortest duration of time taking into account the patient's general condition, the patient's age, weight, and medical history (see sections 4.3 and 4.4). These effects of are mediated by opioid receptors. The receptors are widely distributed in the central nervous system. Receptors are also present to a lesser extent, in vas deferens, knee joints, the gastrointestinal tract, and in the heart and the immune system.

Opium is excreted in human milk, where it reaches higher concentrations than in maternal plasma. A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Dropizol therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman. If Dropizol is used during breastfeeding, infants should be closely monitored for symptoms of respiratory depression and sedation. Dropizol drops should be used with caution in the following conditions / for the following patientsBecause of these risks, concomitant prescribing with these sedative medicines should be reserved for patients for whom alternative treatment options are not possible. If a decision is made to prescribe Dropizol concomitantly with sedative medicines, the lowest effective dose should be used, and the duration of treatment should be as short as possible. Adjustment of dose may be needed in the elderly, patients with thyroid insufficiency, and patients with mild to moderate renal or hepatic impairment (see also section 4.2 and 4.3). There is limited amount of data from the use of opium in pregnant women. Studies in animals have shown reproductive toxicity (see section 5.3). The patients should be followed closely for signs and symptoms of respiratory depression and sedation. In this respect, it is strongly recommended to inform patients and their caregivers to be aware of these symptoms (see section 4.5). The elimination half-life of morphine is approximately 2 hours. An elimination half-life of 2.4 to 6.7 hours has been reported for M3G. About 90 % of total morphine is excreted in 24 hours with traces in urine for 48 hours or more 9.