Canesflor Vaginal Probiotics | Helps Prevent Recurrence of Vaginal Infections such as Thrush | Clinically Proven - 10 Count (Pack of 1)

Product Information

Eligibility criteria were based on the PICOS framework [ 23]: (1) premenopausal nonpregnant women with BV were enrolled (BV was defined by one of three diagnostic tests recommended by widely accepted clinical guidelines [ 24, 25], namely Nugent score [ 26], Amsel criteria [ 27] or Hay/Ison criteria [ 28]); (2) probiotic preparations, single or mixed strains with any dosage, route of administration and preparation types (including capsules, tablets, tampons, pessaries, and effervescent tablets); (3) control arm used placebo or active controls (with an active ingredient including metronidazole, tinidazole, and clindamycin); (4) the outcomes of interest were reported (see Section 2.3); (5) randomized, double- or triple-blind controlled trials with follow-up of at least one menstrual cycle (verification time of BV cure according to guidelines from the FDA [ 29]). Ngugi, B. M. et al. Effects of BV-associated bacteria and sexual Intercourse on vaginal colonization with the probiotic Lactobacillus crispatus CTV-05. Sex. Transm. Dis. 38, 1020–1027 (2011). Buggio, L., Somigliana, E., Borghi, A. & Vercellini, P. Probiotics and vaginal microecology: fact or fancy? BMC Women’s Health 19, 25 (2019). Lactobacillus suppresses the reproduction of fungi bacteria including the Candida Albicans. These vaginal suppositories contain natural harmless substances which nourish your vaginal flora creating the optimum environment needed for a healthy intimate area.

vaginal douche containing > 1.0 × 10 8 colony-forming units/mL of L. acidophilus ( n = 32), or no treatment Lactobacillus crispatus LbV 88, Lactobacillus gasseri LbV 150N, Lactobacillus jensenii LbV 116 and Lactobacillus rhamnosus LbV96 Vicariotto, F., Mogna, L. & Del Piano, M. Effectiveness of the two microorganisms Lactobacillus fermentum LF15 and Lactobacillus plantarum LP01, formulated in slow-release vaginal tablets, in women affected by bacterial vaginosis: a pilot study. J. Clin. Gastroenterol. 48, S106 (2014).Kalia, N., Singh, J. & Kaur, M. Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review. Ann. Clin. Microbiol. Antimicrob. 19, 5 (2020). Using a single strain or mixtures of Lactobacillus strains, especially vaginal L. crispatus, could have many benefits. It avoids the risk of introducing other vaginal bacteria related to vaginosis or infections, such as G. vaginalis and Prevotella species. Once the Lactobacillus strains colonize, the produced lactic acid and bacteriocins could lower vaginal pH, inhibit BV-related pathogens, and potentially prevent BV recurrence in the long term 9, 10, 11, 14. It is easier to culture single bacterial strains in large batches under controlled standard conditions. It is also cheaper for clinical use and prevents the possibility of transferring cells and untested organisms from donor women, as in VMT. Hantoushzadeh, S. et al. Comparative efficacy of probiotic yoghurt and clindamycin in treatment of bacterial vaginosis in pregnant women: a randomized clinical trial. J. Matern Fetal. Neonatal. Med. 25, 1021–1024 (2012). Muzny, C. A. & Schwebke, J. R. Biofilms: an underappreciated mechanism of treatment failure and recurrence in vaginal infections. Clin. Infect. Dis. 61, 601–606 (2015).

All GYNTIMA products undergo a number of clinical tests such as microbiology controls, chemical-physical tests, tests of dermal tolerance and tests of health safety to name but a few to ensure your product exceeds your expectations.

Pharmacy product

Sexual Health and Wellness Institute. Clinical Trial to Survey Results of Flourish Vaginal Care System for Recurrent Bacterial Vaginosis. https://clinicaltrials.gov/ct2/show/NCT03734523 (2021). detecting sialidase produced by pathogens associated with the condition [ 49, 50]. Of note, aerobic vaginitis has also been observe the effects of probiotic-containing yoghurt on BV. The subjects were randomized to one of three treatment

The pH of a substance is a measurement of how acidic or basic it is, on a scale of 0 to 14, with the lower numbers representing greater acidity.Cheng, L. et al. Vaginal microbiota and human papillomavirus infection among young Swedish women. npj Biofilms Microbiomes 6, 39 (2020). Das S., Bhattacharjee M. J., Mukherjee A. K., Khan M. R. (2022). Recent advances in understanding of multifaceted changes in the vaginal microenvironment: implications in vaginal health and therapeutics. Crit. Rev. Microbiol. 21, 1–27. doi: 10.1080/1040841x.2022.2049696 Damelin, L. H. et al. Identification of predominant culturable vaginal Lactobacillus species and associated bacteriophages from women with and without vaginal discharge syndrome in South Africa. J. Med Microbiol 60, 180–183 (2011). and found to be 56% and 62%, respectively, (p = NS). Infection with Candida was reported in 14.3% of subjects Women who used pessaries were randomized to vaginal probiotic suppository use versus without use. The intervention was a vaginal probiotic suppository and moisturizing vaginal gel. The vaginal microenvironment was assessed using Gram stain and Nugent's criteria at baseline and 3 months by a microbiologist blinded to group allocation. Symptoms and experience with use of the probiotic were assessed using questionnaires. The primary outcome was change in lactobacilli count on Nugent subscore at 3 months.

Drekonja, D. et al. Fecal microbiota transplantation for clostridium difficile infection: a systematic review. Ann. Intern. Med. 162, 630 (2015). Thus, it is important to follow the dynamics of the vaginal microbiome for at least 6 months following treatment to assess complete clinical cure endpoints 23. Moreover, restoring the vaginal microbiome after antibiotic treatment (e.g., with probiotics or VMT) will assist the recovery of the vaginal environment and complete the whole treatment procedure (Fig. 1). Therefore, evaluation of additional methods for BV treatment and prevention, especially recurrent BV, will be of great value in the clinic. ProbioticsTachedjian, G., O’Hanlon, D. E. & Ravel, J. The implausible ‘in vivo’ role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota. Microbiome 6, 29 (2018). four intravaginal products. Patients were diagnosed with BV if ≥3 Amsel criteria were present. Each of the four Overall, VMT presents a promising way to combine antibiotic treatment and restoration of the vaginal microbiome to combat vaginosis-related bacteria. It also provides a whole environment, including the mixture of vaginal microbes and molecules produced by both hosts and microbes (e.g., lactic acid, cytokines, bacteriocins, and antimicrobial peptides), which assists in the colonization of essential bacteria while working against BV-associated bacteria 9, 11, 14. These molecules might be essential for the successful re-establishment of a healthy vaginal microbiome.