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Nwosu, Z. C. et al. Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours. J. Exp. Clin. Cancer Res. 37, 211 (2018). Courtney, R. & Landreth, G. E. LXR regulation of brain cholesterol: from development to disease. Trends Endocrinol. Metab. 27, 404–414 (2016). Lee, J. H. et al. Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes. Mol. Cell 35, 806–817 (2009). Engel, T. et al. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. FEBS Lett. 566, 241–246 (2004). Ramona Rudalska, Jule Harbig, Sabrina Klotz, Stefan Zwirner, Liudmyla Taranets, Florian Heinzmann, Thales Kronenberger, Wei Cui, Luana D’Artista, Elias Einig, Martina Hinterleitner, Agata Dylawerska, Tae-Won Kang, Antti Poso, Nikita Popov, Lars Zender & Daniel Dauch
Wang, B. et al. Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis. Cell Stem Cell 22, 206–220 e204 (2018). I finally found something I can take and what really improves my hair, skin, nails etc in visible way. I’m extremely happy with LXR Vitamins and highly recommend it to all.Janowski, B. A. et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc. Natl Acad. Sci. USA 96, 266–271 (1999). Sebolt-Leopold, J. S. & Herrera, R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat. Rev. Cancer 4, 937–947 (2004). Kay, H. Y. et al. Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding. Antioxid. Redox Signal. 15, 2135–2146 (2011).
Zhang, L. et al. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. eLife 6, e28766 (2017). Flavoured with real juice, this delicious performance + hydration blend combines bold blueberry and açai notes with electrolytes, vitamins, antioxidants, and green tea extract. Apfel, R. et al. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14, 7025–7035 (1994). Zhang, X. et al. Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRα–SREBP1c-dependent mechanism. J. Diabetes 6, 212–220 (2014).US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01651273 (2013). Dietschy, J. M. Central nervous system: cholesterol turnover, brain development and neurodegeneration. Biol. Chem. 390, 287–293 (2009). a, Representative western blot analysis of Nrf2, Akt-1 and LXRα in different human HCC cells (cropped blot images, n = 3 independent experiments). β-actin was used as a loading control. b, LXRE reporter assay in different human HCC cells upon lentiviral infection of pL-LXRE-GFP (GFP measurements in individual cells; values represent mean ± SD, n = 5 independent experiments, statistical significance was calculated using two-tailed Student´s t test). c, Weight development of CB17.Cg-Prkdc scidLyst bg/Crl mice upon subcapsular injection of HuH7 cells into the liver and treatment with T0901317/sorafenib or carrier (values represent mean ± SD, n = 6 mice per group statistical significance was calculated using two-tailed Student´s t test). Unprocessed images of the blots and numerical source data are provided as source data files.
American Fizz is one of the largest importers and distributors of American Food and Groceries, Candy and Sweets, Soda and Energy Drinks here in the UK. Our wide product range, exclusive imports and unbeatable prices are the best in the United Kingdom. a, Quantification of Myc OE; Akt1 Myr tumor nodules from mice that were treated for 7 weeks with sorafenib, BI-882370 or carrier +/− T0901317 (values represent mean ± SD, n = 4 mice per group, statistical significance was calculated using two-tailed Student´s t test). b-d, Treatment of Myc OE; Akt1 Myr; gNr1h3 or Myc OE; Akt1 Myr;gNC HCCs with T0901317/sorafenib or carrier. Representative pictures of livers upon a 6-week therapy ( c, n = 3 mice per group) and survival of mice under treatment ( d, Kaplan-Meier curve, statistical significance was calculated using a log-rank test, n = 6 mice per group). Scale bars, 1 cm. Numerical source data are provided as source data files. Rajamaki, K. et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS ONE 5, e11765 (2010). McCullough, K. D., Martindale, J. L., Klotz, L. O., Aw, T. Y. & Holbrook, N. J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21, 1249–1259 (2001).I’ve been searching for good vitamins since long time. I’m allergic to gelatine capsules and cannot take any vitamins... Venkateswaran, A. et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc. Natl Acad. Sci. USA 97, 12097–12102 (2000). Bodzioch, M. et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat. Genet. 22, 347–351 (1999). Griffett, K. et al. The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. Mol. Metab. 4, 353–357 (2015). Fu, X. et al. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J. Biol. Chem. 276, 38378–38387 (2001).
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