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PubMed: In-chain neutral hydrocarbon loss from crocin apocarotenoid ester glycosides and the crocetin aglycon (Crocus sativus L.) by ESI-MS(n) (n=2, 3). One interesting recent clinical study was however published in 2015. The researchers looked at the effects of saffron on thirteen patients suffering from liver cancer while they were undergoing chemotherapy treatment. The patients were divided into two groups and either treated with saffron or given a placebo. PubMed: Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. PubMed: Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats. PubMed: Picrocrocin kinetics in aqueous saffron spice extracts (Crocus sativus L.) upon thermal treatment.
While these findings are promising, longer human studies with more participants are needed before experts can recommend saffron as a treatment for depression. SummaryPubMed: Flavonoid Determination in the Quality Control of Floral Bioresidues from Crocus sativus L. PubMed: Catalytic properties of three L-lactate dehydrogenases from saffron corms (Crocus sativus L). PubMed: Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. PubMed: The Effect of Chronic Administration of Saffron (Crocus sativus) Stigma Aqueous Extract on Systolic Blood Pressure in Rats. PubMed: Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol.
One of the major causes of weight gain is hunger pangs. Those who find it difficult to control their hunger end up eating too much which contributes to weight gain in the long run. Using saffron oil in your diet can help you control hunger pangs which reduces your daily calorie consumption. In the long run, this contributes to weight loss. PubMed: Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. PubMed: Characterization of a glucosyltransferase enzyme involved in the formation of kaempferol and quercetin sophorosides in Crocus sativus. A number of studies have demonstrated that saffron has the potential to prevent and treat cancer. Research is at an early stage but the signs are good. According to the studies done so far, saffron and its major constituent – crocin may have an important role to play in the battle against various forms of cancer.Overall, you might benefit from using saffron, whether the spice or oil form, if you have wounds that need to be treated, you need a mental health boost, or you would like glowing and toned skin. There have been some studies that have shown saffron may be able to help pregnant women in certain ways, including helping to prevent the need for a cesarean section, but you should speak with your doctor before trying this, as other studies have shown that saffron has been used to terminate pregnancies. PubMed: DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from kashmiri saffron in a human pancreatic cancer cell line.
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