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In sensitive patients, concurrent use with alcohol or other CNS depressants may cause additional reductions in alertness and impairment of performance. The decrease in cetirizine clearance in these elderly volunteers appeared to be related to their decreased renal function.
Hayfever and Allergy Relief 10mg Tablets (Cetirizine Hayfever and Allergy Relief 10mg Tablets (Cetirizine
Renally impaired patients: The pharmacokinetics of the drug were similar in patients with mild impairment (creatinine clearance higher than 40 ml/min) and healthy volunteers. Clinical studies have shown that cetirizine at the recommended dosage has minor undesirable effects on the CNS, including somnolence, fatigue, dizziness and headache.At the recommended dosage, cetirizine has demonstrated that it improves the quality of life of patients with perennial and seasonal allergic rhinitis. If you’re allergic to a particular allergen, you may suffer from a mild cough or a sneeze attack – but for others the symptoms can be much more severe and can even lead to death. g. spinal cord lesion, prostatic hyperplasia) as cetirizine may increase the risk of urinary retention.
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Patients with moderate to severe renal impairment: there are no data to document the efficacy/safety ratio in patients with renal impairment.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take cetirizine film-coated tablet. Elderly: Following a single 10 mg oral dose, half-life increased by about 50 % and clearance decreased by 40 % in 16 elderly subjects compared to the normal subjects. Undesirable effects are described according to MedDRA System Organ Class and by estimated frequency based on post-marketing experience. Elderly subjects: data do not suggest that the dose needs to be reduced in elderly subjects provided that the renal function is normal. The distribution of pharmacokinetic parameters such as peak plasma concentration (Cmax) and area under curve (AUC), is unimodal in human volunteers.